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Despair

dɪˈspɛː

Despair definitions
noun
despair despairs
  1. the complete loss or absence of hope

    "a voice full of self-hatred and despair"

verb
despair despaired despairing despairs
  1. lose or be without hope

    "we should not despair"

    lose hope give up hope abandon hope give up lose heart be discouraged be despondent be demoralized resign oneself throw in the towel/sponge quit surrender hopeless desperate anguished distressed broken-hearted heartbroken grief-stricken inconsolable sorrowing suicidal in despair