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Vicissitude

vɪˈsɪsɪtjuːd

Vicissitude definitions
noun
vicissitude vicissitudes
  1. a change of circumstances or fortune, typically one that is unwelcome or unpleasant

    "close friendships are supposed to sustain us through such vicissitudes"

  2. alternation between opposite or contrasting things

    "the vicissitude of the seasons"